Endocrine Abstracts

A 24-year old male was referred to endocrinology outpatient with absence of hair on scalp, eyebrows, eyelids, and body since birth, short stature, bone pains, proximal muscle weakness, and recurrent fractures of long bones. He was a product of second degree consanguineous marriage. He was eldest of two siblings. His younger brother aged 16-years was suffering from similar complaints.Clinical examination revealed alopecia universalis, short stature, hypot...

A 75 year old woman was treated for over three years with the somatostatin analogue, octreotide for insulinoma. She had presented in a hypoglycaemic coma. C-peptide and insulin levels were both raised. Cortisol, TSH, a gut hormone screen and urinary sulphonylurea levels were all normal. No adenoma was identified on CT or MRI scanning but angiography showed an area of increased vascularity within the pancreas. At laparotomy no lesion was found and no resection was undertaken. B...

IntroductionFacing the repeated failures of the medical management of obesity, bariatric surgery offers a promising therapeutic option in terms of achieving weight loss and metabolic benefits. Our study aimed to assess the impact of sleeve gastrectomy on uric acid metabolism in obese subjects.MethodsThis was a repeated retrospective cross-sectional study including 40 obese patients who were followed up at the...

Background: Ferroptosis is an emerging form of regulated necrotic cell death characterized by excessive lipid peroxidation. Adrenocortical carcinoma (ACC) cells have been shown to be highly susceptible to ferroptosis caused by active steroid hormone synthesis. While therapeutic activation of ferroptosis has been proposed as a novel treatment strategy, its impact on the tumor immune microenvironment (TIME) remains elusive. Macrophages are an important TIME component and modulat...

The prevalence of type 2 diabetes (non-insulin dependent diabetes) has been universally acknowledged as a chronic public health concern and the leading cause of mortality on a global scale. Plant-based bioactive compounds have made significant contributions to the management of diabetes mellitus globally. Artocarpus heterophyllus, also known as “kathal” in the subcontinent, is rich in dietary fibre and has traditionally been used as a diabetes remedy. The current stu...

Introduction: Severe HTG usually occurs in a patient with genetic predisposition encoding various apolipoproteins (APOE, APOA5, APOC2, APOB), lipoprotein lipase (LPL), exacerbated by secondary factors as diabetes, obesity, high alcohol intake Case report: 35 yr old diabetic male presented with repeated vomiting with severe epigastric pain He had similar attack 1 year ago diagnosed as acute pancreatitis. 3 years ago he was diagnosed SLE with antiphospholi...

Introduction: The aetiology of a diabetic foot ulcer is multifactorial. The three principal components that ascertain the likelihood of ulceration in a diabetic foot are peripheral neuropathy, repeated minor trauma and deformity. Aims:To find the prevalence of diabetes patients having the foot at risk using the Simplified 60-Second Diabetic Foot Screen tool (SSDFST).Objectives: To find out the diabetic foot at risk.1. To ascertain the dispersal of variou...

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abste...

In 2022, a 63 year old woman was referred for assessment of a six month history of gastro-oesophageal reflux symptoms and dysphagia. Upper gastrointestinal (GI) endoscopy was normal apart from mild reflux oesophagitis. A computerized tomography (CT) scan demonstrated a 2 cm nodule medial to the caudate lobe of the liver, a 1.5 cm nodule in the right lung base and two further sub cm nodules in the right lung lobe. In terms of background, the patient had a benign breast lump und...

Addison’s disease (AD) occurs when 90% of the cortex of Adrenal Glands is affected. Most common causes of AD are autoimmune destruction, tuberculosis, hemorrhage due to meningococcal meningitis, metastatic cancers and adrenoleukodystrophy. AD is associated with other autoimmune disorders e.g., vitiligo, type-1 diabetes or hypothyroidism. Due to non-responsiveness of adrenals to Adrenocorticotrophic hormone (ACTH), α-melanocyte stimulating hormone levels increases and...